I've found the same thing. The larger pills I have to break up and take a piece at a time, but have definitely not had a problem with it. I find that it's better though if I am standing when I take them. I learned that the hard way, I am used to rolling over and taking a pain pill for my back in the a.m. and then rolling over and waiting for it to work - so a minor drawback, I have to get up and take it in two pieces, but that works I get them down, make sure I feel okay then relax and wait for them to work. Maybe once all this weight it off, I won't need them to get out of bed in the a.m. I'm sure it will do my back a lot of good to have about 100 less pounds hanging off of it.